Top 10 Supplements for Arthritis

1908241_265522013612275_327835229_nResearch hasn’t always kept pace with the popularity of supplements. But more natural medicines are being put to the test in well-designed clinical trials. Here are nine supplements that are backed by science and shown to be effective in the treatment of rheumatoid arthritis (RA), osteoarthritis (OA) and arthritis-related conditions.



2. SAM-e (S-adenosylmethionine)
How it works: SAM-e acts as an analgesic (pain reliever) and has anti-inflammatory properties. It may stimulate cartilage growth and also affects neurotransmitters, such as serotonin, which reduce pain perception. Two studies have shown that it relieves OA symptoms as effectively as non-steroidal anti-inflammatory drugs (NSAIDs) with fewer side effects and more prolonged benefit.
Best for: osteoarthritis
Also used for: fibromyalgia

3. Boswellia Serrate (Indian frankincense)
How it works: The active components (Boswellic acids) have anti-inflammatory and analgesic (pain-relieving) properties. It also may help prevent cartilage loss and inhibit the autoimmune process. In a 2008 study, the extract, also known as Loxin 5, significantly improved OA pain and function within seven days. An Indian study also revealed it slowed cartilage damage after three months of use.
Best for: osteoarthritis

4. Capsaicin (Capsicum frutescens)
How it works: Capsaicin temporarily reduces substance P, a pain transmitter. Its pain-relieving properties have been shown in many studies, including a 2010 study published in Phytotherapy Research, which revealed a 50 percent reduction in joint pain after three weeks of use. It is available as a topical cream, gel or patch.
Best for: osteoarthritis
Also used for: rheumatoid arthritis and fibromyalgia

5. Tumeric/Curcumin (Curcuma longa)
How it works: Curcumin is the chemical in turmeric that can reduce joint pain and swelling by blocking inflammatory cytokines and enzymes. A 2010 clinical trial using a turmeric supplement showed long-term improvement in pain and function in patients with knee OA. A small 2012 study using a curcumin product, BCM-95, showed more reduced joint pain and swelling in patients with active RA when compared to diclofenac sodium.
Best for: osteoarthritis
Also used for: rheumatoid arthritis

6. Avocado-soybean Unsaponifiables (ASU)
How it works: ASU blocks pro-inflammatory chemicals, prevents deterioration of synovial cells, which line joints, and may help regenerate normal connective tissue. A large three-year study published in 2013 showed that ASU significantly reduced progression of hip OA compared with placebo. A 2008 meta-analysis found that ASU improved symptoms of hip and knee OA, and reduced or eliminated NSAID use.
Best for: osteoarthritis

7. Cat’s Claw (Uncaria tomentosa)
How it works: Cat’s claw is an anti-inflammatory that inhibits tumor necrosis factor (TNF), a target of powerful RA drugs. It also contains compounds that may benefit the immune system. A small 2002 trial showed it reduced joint pain and swelling by more than 50 percent compared with placebo. Look for a brand that is free of tetra-cyclic oxindole alkaloids.
Best for: rheumatoid arthritis

8. Fish Oil (Omega-3 fatty acids EPA and DHA)
How it works: Omega-3s block inflammatory cytokines and prostaglandins, and are converted by the body into powerful anti-inflammatory chemicals called resolvins. EPA and DHA have been extensively studied for RA and dozens of other inflammatory conditions. A 2010 meta-analysis found that fish oil significantly decreased joint tenderness and stiffness in RA patients and reduced or eliminated NSAID use.
Best for: rheumatoid arthritis
Also used for: osteoarthritis, Sjögren’s syndrome

9. Gamma Linolenic Acid (GLA)
How it works: GLA is an omega-6 fatty acid that the body converts into anti-inflammatory chemicals. In one trial, 56 patients with active RA showed significant improvement in joint pain, stiffness and grip strength after six months and progressive improvement in control of disease activity at one year. A smaller study found that a combination of GLA and fish oil significantly reduced the need for conventional pain relievers.
Best for: rheumatoid arthritis

10. Ginger (Zingiber officinale)
How it works: Ginger has been shown to have anti-inflammatory properties similar to ibuprofen and COX-2 inhibitors. In a 2012 study, a specialized ginger extract reduced inflammatory reactions in RA as effectively as steroids did. Earlier studies showed that taking a certain extract four times daily reduced osteoarthritis pain in the knee after three months of treatment, and another taken twice daily worked about as well as ibuprofen taken three times daily for hip and knee OA pain.
Best for: rheumatoid arthritis and osteoarthritis

Honorable Mention: Protandim
How it works: Made up of 5 natural herbs Bacopa, Ashwagandha, Green Tea, Turmeric and Milk Thistle. Protadim most famously know to turn on your NrF2, which are your survival genes. It up regulates your glutathione 300% in 30 days. This helps your body to perform at its best.You recover faster, less inflammation which leads to less arthritis pain. One pill a day keeps your Nrf2 genes up and running and keep your arthritis pain down.

Best for: rheumatoid arthritis, osteoarthritis, fibromyalgia

Talk to your doctor before taking a supplement so you understand the potential side effects and interactions with your medication. The Food and Drug Administration (FDA) does not test supplements, but there are private companies that do. Be sure to research these products and share the information with your doctor. You can find supplement information on The National Institutes of Health (NIH) Medline Plus website.

Read about nine supplements that are backed by science and shown to be effective in treating RA, OA and arthritis-related conditions.

Oxidative stress & oral-systemic health

What does oxidative stress have to do with oral-systemic health? The answer to this question is a topic that has many layers to it, and the data surrounding this topic is an area of current explosion in medical and dental literature. My guess is that many colleagues and dental team members are somewhat foggy on the topic, but the reason it is important to grasp this is because — as the science surrounding chronic inflammation continues to unfold — oxidative stress appears to be a player in the cascade of events that link oral and systemic health. Antioxidants themselves could be helpful in interrupting that cascade.A logical place to begin is with explanations that may remind you of your physics class, but I challenge you to take a moment to digest this as it helps in understanding the oral/systemic connection. The body is made up of many types of molecules, atoms, and cells. Atoms within the body are considered to be stable when every electron in the outermost shell has a complementary electron that spins in the opposite direction.

Free radicals involving oxygen or reactive oxygen species (ROS) refer to atoms with at least one unpaired electron in the outermost shell, and as a result are unstable or reactive. To become stable, they must obtain or “steal” an electron from another molecule, which can begin a chain reaction of “electron stealing,” and the production of more free radicals as shown in Figure 1. Antioxidants can also contribute an electron to a free radical, thereby stabilizing the molecule. While some free radicals occur naturally, and some are produced by the body’s immune system to help neutralize viruses and bacteria, it is the excess of free radicals that becomes dangerous to our health.

Oxidative stress refers to the imbalance of too many free radical molecules and can lead to damage of the cell membrane, DNA, protein, and fats. It is this cellular damage which, in turn, can lead to the aging process and degenerative diseases such as cardiovascular diseases, aging, immune dysfunction, Alzheimer’s disease, diabetes, and even cancer.
In the case of diabetes and its subsequent impact on the development of cardiovascular disease, there is growing evidence that excess generation of highly reactive free radicals (largely due to hyperglycemia), causes oxidative stress, which is a major risk factor for the development of heart-muscle disease referred to as cardiomyopathy.1 Studies have also implicated oxidative stress and decreased antioxidant capacity to the development of oral squamous cell carcinoma.2,3
The oral environment is especially susceptible to damage from free radicals because the mucous membrane allows for rapid absorption of various substances, which contribute to oxidative stress such as hydrogen peroxide in whitening products, alcohol, nicotine, and even some dental materials used in restorations. Periodontal infection can also contribute to the development of oxidative stress, and oxidative stress in and of itself can exacerbate inflammation both in the oral cavity and systemically.
A recent study published in the Journal of Dental Research titled, “Oxidative Stress, Systemic Inflammation, and Severe Periodontitis,” set out to examine the association between oxidative stress and systemic inflammation in people with severe periodontitis.4 They compared measurements of oxidative stress and blood antioxidant potential and measured C-reactive protein, interleukin-6, total HDL, LDL cholesterol, and triglyceride levels on individuals with severe generalized periodontitis and compared measurements against control individuals with no history or clinical signs of periodontitis. Results revealed that individuals with severe periodontitis exhibited higher oxidative stress levels, and lower total antioxidant capacity compared to healthy individuals — independent of age, gender, smoking habits, ethnicity, and standard differences in the overall lipid panel. Oxidative stress levels were positively correlated with levels of CRP and clinical periodontal parameters. The authors concluded “that severe periodontitis is independently associated with increased oxidative stress and reduced antioxidant capacity.”

Researchers Chapple and Matthews published a comprehensive review of free radicals and antioxidants in periodontal destruction and their data suggests that oxidative stress lies at the heart of periodontal tissue damage that results from host-microbial interactions.5 The cascade of events that results in tissue damage is either directly involved as the result of excess ROS activity and antioxidant deficiency; or indirectly involved as a result of creating a pro-inflammatory state.

Incorporating antioxidants into therapy
It is the researchers’ conclusion that improved understanding in these pathways provides opportunities for the development of novel antioxidant therapies, which could function not only as antioxidants but also as anti-inflammatory agents.
To that point, dental professionals should be aware of a line of products by PerioSciences which provide antioxidants for topical application, and immediate absorption into the oral tissues, which can help to offset oxidative stress, thereby improving conditions such as lichen planus, xerostomia due to chemotherapy, geographic tongue, and many other tissue irritations. AO ProVantage and AO ProVantage Blast are antioxidant gels that contain ferulic acid, a polyphenol found in seeds and leaves of plants, and phloretin, a flavonoid derived from apples, strawberries, and tomatoes, along with thymol, essential oils, and xylitol.

The mouthwash from PerioSciences includes the antioxidants ferulic acid, curcuminoids, and green tea catechin along with essential oils. An interesting study published in the November 2010 Journal of Periodontology investigated the effects of ferulic acid and phloretin on cells impregnated with nicotine and found that concentrations of these antioxidants literally helped to counteract many of the deleterious effects of nicotine when added to the cells.

Dietary methods for increasing antioxidant capacity include significant increases in antioxidant-rich foods such as pomegranates, strawberries, blueberries, raspberries, walnuts, sunflower seeds, ginger, and bright colored vegetables. Sustaining a diet rich in antioxidants every day is somewhat unrealistic for many individuals. Therefore, the addition of antioxidant supplements that have been shown to have high bioavailability for absorption, such as Juice Plus or Life Pak Nano by Pharmanex, should be considered as an adjunct for patients with periodontal disease, or for those wishing to prevent it.

As I have mentioned in previous columns, seemingly exhaustive information is available from on the topics of oxidative stress and antioxidants. As the interaction between oral and systemic health becomes even clearer, it is apparent that intercepting and treating periodontal infections, and decreasing oxidative stress in the oral environment have the potential for reducing the overall burden of oxidative stress systemically. That should be considered a win-win for oral and systemic health!

1. Thandavarayan RA, Diridharan VV, Watanabe K, Konishi T. Diabetic cardiomyopathy and oxidative stress: role of antioxidants. Cardiovasc Hematol Agents Med Chem 2011; Sept . 9 [Epub ahead of print].
2. Korde SD, Basak A, Chaudhary M, Goyal M, Vagga A. Enhanced nitrosative and oxidative stress with decreased total antioxidant capacity in patients with oral precancer and oral squamous cell carcinoma. Oncology 2011;80:382-389.
3. Patel JB, Shah FD, Shukla SN, Shah PM, Patel PS. Role of nitric oxide and antioxidant enzymes in the pathogenesis of oral cancer. J Cancer Res Ther 2009;5:247-253.
4. D’Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative stress, systemic inflammation and severe periodontitis. J Dent Res 2010;89:1241-1246.
5. Chapple ILC, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000 2007;43:160-232.
6. San Miguel SM, Opperman LA, Allen EP, Zielinski J, Svoboda KH. Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells. J Periodontol 2010: 81:1675-1690.
Antioxidants, free radicals, and oxidative stress

Antioxidants, free radicals, and oxidative stress

Discovered! New mechanisms of oxidative stress regulation

Regulation of oxidative stress is critical to cell survival. New preclinical research from Roswell Park Cancer Institute (RPCI) has revealed two key mechanisms by which oxidative stress is regulated in normal and cancerous cells.

Oxidative stress occurs when a cell is not able to adequately remove reactive oxygen species (ROS), or reactive molecules that result from the metabolism of oxygen. To alleviate these toxically high levels of ROS, cells activate NF-E2-related transcription factor 2 (Nrf2), which normally resides in the cytoplasm. Under conditions of oxidative stress, however, Nrf2 relocates to the nucleus, where it induces transcription of antioxidant genes.

For many years, ROS detoxification was considered the major function of Nrf2. Reciprocally, activation of Nrf2 was considered the major and universal mechanism for ROS detoxification.

Writing in the journal Molecular Cell, a team led by Mikhail Nikiforov, PhD, a Professor of Oncology and member of the Department of Cell Stress Biology at RPCI, has demonstrated that under certain conditions, Nrf2 behaves in ways that are directly opposite to its normal activities. These scientists have shown that if intracellular ROS exceed a critical threshold, Nrf2 induces expression of the transcription factor Klf9 (Kruppel-like factor 9), which in turn further increases ROS levels by suppressing cellular antioxidant genes, ultimately leading to cell death. The team verified this previously unrecognized feed-forward mechanism of ROS regulation in vivo using an animal model of idiopathic pulmonary fibrosis, a terminal disease of the lungs.

Reactive oxygen species play a dual role in tumorigenesis. While low ROS levels promote tumor cell proliferation and increase genetic instability, high amounts of ROS are detrimental to cell proliferation or survival, inhibiting both healthy and diseased cells. The team’s findings identify Klf9 as a molecular “switch” between the anti- and pro-oxidative functions of Nrf2.

“Tumor cells exhibit increased generation of reactive oxygen species as a consequence of high metabolic activity. Consequently, tumors often develop adaptive mechanisms to suppress high levels of ROS, so we looked for ways to exploit their weakness in the face of ROS increase,” notes Dr. Nikiforov. “Our findings suggest that Klf9 depletion could be beneficial for malignancies where high amounts of ROS hinder tumor progression, including colorectal and gynecologic cancers. Our data may also support a role for Klf9 as a general tumor suppressor and provide further insights into the mechanism by which tumors acquire resistance to higher levels of ROS.”

Activation of Klf9 may prove to be an effective complement to therapies that induce oxidative stress as a mechanism of cell killing, including cisplatinum, arsenic trioxide and the experimental agent elesclomol. Dr. Nikiforov and his team have begun subsequent studies to elucidate the role of Klf9 and its targets in tumor progression and drug resistance of several difficult-to-treat cancers, including melanoma and multiple myeloma.

This work has been supported in part by two National Institutes of Health (NIH) grants: awards R01CA120244, from the National Cancer Institute (NCI), and R01AI079253, from the National Institute of Allergy and Infectious Diseases (NIAID). Additional funds were provided by grant RSG-10-121-01 from the American Cancer Society (ACS).

The paper, “Nrf2 amplifies oxidative stress via induction of Klf9,” was published online ahead of print today and can be accessed at team uncovers new mechanisms of oxidative stress regulation

University of Arizona’s College of Pharmacy has discovered a molecular pathway NrF2

(Medical Xpress)—A team of researchers in the University of Arizona’s College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse the progression of end-stage liver disease.

Although cirrhosis of the liver is most commonly associated with alcohol or drug abuse, the condition – marked by scar tissue replacing healthy liver tissue – also can result from viral hepatitis, obesity and diabetes, as well as certain inherited diseases. According to the National Institutes of Health, cirrhosis is the 12th leading cause of death by disease in the U.S.

As with many other human pathologic conditions, end-stage liver disease goes hand in hand with oxidative stress, which refers to damage inflicted to biological tissues by reactive oxygen molecules. Such molecules, also called free radicals, occur naturally as a byproduct of metabolic processes in the body and are associated with many chronic diseases including cancer, diabetes, neurodegenerative and cardiovascular diseases.

“Cells keep oxidative stress under control through various mechanisms,” said Donna Zhang, a professor in the UA Department of Pharmacology and Toxicology, explaining that most of these mechanisms involve Nrf2, a protein present in virtually every cell that acts as a molecular switch. Nrf2 activates various biochemical mechanisms inside the cell that capture reactive oxygen molecules or dispose of damaged cellular components before they can cause more trouble. The antioxidants found in many fruits and vegetables exert their healthful benefits by capturing reactive oxygen molecules.
Under normal, healthy conditions, when no oxidative stress response is needed, an enzyme called Keap1 constantly chews up Nrf2, keeping its level low.
“Then, under stress from reactive oxygen molecules, or when you eat antioxidants from certain plants like broccoli sprouts, it prevents Keap from eating up Nrf2, allowing it to accumulate in the cell,” Zhang explained. “Nrf2 then activates the cellular antioxidant response. That is how antioxidants work.”


Donna Zhang is especially interested in how antioxidants found in plants help cells fight stress from reactive oxygen molecules. Credit: Daniel Stolte/UANews

According to conventional wisdom, our bodies turn on their Nrf2-mediated protection pathway when subjected to high oxidative stress to limit the damage from the destructive oxygen compounds. During liver cirrhosis, Nrf2 should be induced by oxidative stress, but for reasons unclear until this study, this does not happen.

“This was a puzzle before we did our study,” she said. “Somehow the protective mechanism mediated by Nrf2 is compromised by another factor, other than Keap1, in liver cirrhosis.”

Adding to the mystery is the fact that drugs aimed at inhibiting Keap from chewing up Nrf2 have proven ineffective in a cirrhotic liver.

When Zhang and her colleagues studied tissue samples from a human cirrhotic liver, they discovered the reason behind the inexplicably low Nrf2 levels in the face of rampant oxidative stress.
It turned out that another enzyme chews up Nrf2 and prevents the much-needed antioxidant response, exacerbating the disease process. That protein, Hrd1, is part of the cells’ garbage disposal – it specializes in destroying misfolded proteins before they can accumulate and damage cell components.
Under normal conditions, Hrd1 levels are low, so it does not interfere much with Nrf2, explained Zhang. As liver cirrhosis progresses, excessive inflammation triggers the garbage-mediated stress response and Hrd1 becomes very abundant and begins chewing up Nrf2.

The discovery could change the way scientists develop therapeutics, as it provides a new target for future drugs. In laboratory experiments, Zhang and her colleagues were able to restore Nrf2 levels in cirrhotic liver tissue by inactivating Hrd1, effectively reversing liver cirrhosis in mice.

“Previous efforts only focused on the Keap protein and tried to prevent it from breaking down Nrf2,” Zhang said. “Now we know there is a second player in the game – Hrd1 – that we need to inhibit in order to restore Nrf2 levels.
“Boosting Nrf2 is good for protection in general, which is why you should always eat your broccoli,” she stressed.

Scientists make critical end-stage liver discovery

5 Easy Steps To Clean Up Your Diet

1. Keep Hydrated
Research has found that about 90 percent of people are chronically dehydrated which is having a massive impact on their quality of life. It amazes me that people say they don’t often drink water! How they do they get through the day?

Getting properly hydrated will make a huge difference to your health, energy, vitality, and immunity. Everything is influenced by the quantity and quality of the water you drink.

Hydration Action Steps
Drink 6-18 cups of water each day. A good rule of thumb is to drink half your body weight in ounces each day.
Drink lemon water: 2 cups of luke warm filtered water with the freshly squeezed juice from 1/2 lemon. It helps cleanse the digestive system, ignite your metabolism and buffer excess acids. Despite the lemons being acidic in their natural form, lemon water is alkaline forming to the body once consumed.
Enjoy organic herbal teas such as Rooibos, peppermint and nettle.

2. Go Green!
There is conflicting information about which foods are alkaline and which are acid-forming. This simple rule covers 90 percent of foods:

Alkaline foods are those that you already know are good for you: fresh vegetables, salads, leafy greens, low-sugar fruits, nuts, seeds and healthy oils, unrefined, organic, high-water content foods.

Acidic foods are those that you already know are not great for you in excess: refined foods, fast foods, trans-fats, meat, dairy, sugar, caffeine, white bread, white pasta and rice, condiments, alcohol, chocolate, chips, ice cream and pizza.

Aim for a ratio of 80/20: Consume 80 percent alkaline foods to 20 percent acidic foods. For a full list of alkaline foods visit Food Matters here:

3. Adding
Take it slowly! People who try to be perfect from day one miss the chance to learn, experiment and find meals that work for them and their family. They end up feeling hungry, fed up and restricted. It is far better to transition and get there slowly, by sticking to it for the long term rather than being perfect for a day or two and then crashing. Keep the focus on adding more and more alkaline foods each day!

4. Oxygen
A simple breathing exercise once or twice a day will give your body a huge helping hand in removing excess acids from your bloodstream. Plus it allows you to stop, focus your mind, visualise and relax, which is also nice.

Sit comfortably, close your eyes and follow this simple breathing pattern:

Breathe in for the count of 4.

Hold for a count of 8.

Breathe out for a count of 4.

Repeat 10 times.

5. Supplements
There are so many supplements out there, all promising different things and all claiming they are better than the others.

Here are some core supplements that are particularly important for cleansing and alkalising your bloodstream:
Green powder: This is a combination of powdered grasses, fruits, vegetables and sprouts with a focus on wheatgrass and barley grass.
Alkaline water: You can make alkaline water in a number of ways including using a water ionizer, pH drops or adding freshly squeezed lemon.
Alkaline minerals: The primary way that your body buffers acids is through the alkaline minerals: sodium, magnesium, potassium and calcium.
Cleansing your body is simple when taken slowly when you focus on adding rather than perfection and when you still allow yourself treats and fun. Take it easy, have a sense of humor with it and enjoy it. Keep it simple and if you mess up, don’t beat yourself up! Go for a walk, refocus and just start again! The rest of your life is a long and interesting journey, so enjoy it with the health, energy and vitality you deserve!

By Ross Bridgeford – source:

Featured Teacher: Kris Carr
Kris Carr is a New York Times bestselling author, speaker, health advocate and wellness coach.

Her diagnosis of a rare stage four cancer in 2003, for which there is no treatment or cure, inspired Kris to learn everything she could about proper nutrition and self-care and in the process, she stabilized her cancer. She is the director and the subject of the documentary, Crazy Sexy Cancer and the author of the revolutionary Crazy Sexy Cancer book series. Kris lectures regularly at medical schools, hospitals, wellness centers, corporations, and universities throughout the United States.

In this short video, listen to Kris Carr explain:
The amazing health benefits of following a pH balanced diet using the 80/20 principle
Why the Standard American Diet (SAD) is the perfect environment for disease and illness to thrive in
How you can balance your consumption of alkaline and acid foods in your daily diet for optimal health.

Five Tips To Longer Life

…from the Chapter, “Antioxidants Are Killing You” from Dr. Shawn Talbott’s forthcoming book,

Why Your Daily Vitamins May Be Causing Problems and Shortening Your Life (and How You Can Turn on Your Body’s Own Antioxidants for Optimal Health)

By: Shawn M. Talbott, PhD, LDN, CNS, FACSM, FAIS, FACN

Here are my “Five Tips To Help You Live Longer”


  1. Eat a Rainbow Everyday: Focus your efforts on consuming 5-10 servings of brightly-colored fruits and vegetables every day. The brighter the better, because brightness indicates a higher (and still safe) concentration of protective antioxidant nutrients.
  2. Your Food is Your Pharmacy: Forget about “taking” antioxidants and start “making” your own antioxidants (by naturally activating the Nrf2 pathway).Effective ways to naturally activate the Nrf2 pathway include:
  3. Keep It Moving: Exercise – which “turns on” certain antioxidant systems.
  4. Turn Off Eating (Periodically): Intermittent fasting also turns on Nrf2 and survival genes.
  5. Got “Nerf?”: Many foods and herbs have a general activation effect on the Nrf2 “detox” pathway. Nrf2-activating foods include blueberries, tea, broccoli, and cabbage. Nrf2-activating herbs include milk thistle, bacopa, ashwagandha, green tea, and turmeric – all of which are found in Protandim, which uniquely activates Nrf2 and is patented for reducing oxidative stress.

Study on Oxidative Stress Presented at Experimental Biology Conference

LifeVantage Announces Results of Protandim(R) Study on Oxidative Stress Presented at Experimental Biology Conference

(GLOBE NEWSWIRE) — LifeVantage Corporation (LFVN), a company dedicated to helping people achieve healthy living through a combination of a compelling business opportunity and scientifically validated products, announced today that its most recent study on Protandim was presented at the 2014 Experimental Biology Conference held April 26-30, in San Diego, California.

Experimental Biology is an annual meeting attended by more than 14,000 scientists. The theme at the annual meeting of professional research scientists was “Transforming the Future through Science.” Researchers from Colorado State University presented a study entitled Oxidative Stress is Decreased with Short-Term Protandim Use. The placebo-controlled double-blind study supplemented 33 overweight/obese adults, ages 45-69 for 30-days with LifeVantage’s Protandim formula currently sold in Japan. Results indicated a significant reduction in markers of oxidative stress in subjects receiving this Protandim formulation.

Dr. Shawn Talbott, LifeVantage Chief Science Officer commented, “We are pleased to see clinical studies involving our unique products. This research will be added to our large and growing portfolio of scientific studies and builds on the growing collection of evidence supporting Nrf2 activation and oxidative stress reduction associated with Protandim. In addition, this study demonstrates that both of our formulations of Protandim are potent oxidative stress reducers. This allows us to offer people a powerful Nrf2 activator and oxidative stress reduction product in most jurisdictions.”

Abstracts of the conference can be found at the Journal of the Federation of American Societies for Experimental Biology:

Rebecca Scalzo, Janelle Davis, Joseph Beals, Laurie Biela, Gregory Giordano, Hunter Paris Benjamin Miller, Karyn Hamilton, and Christopher Bell, (2014) Oxidative stress is decreased with short-term Protandim use when piperine is substituted for ashwagandha (LB399) FASEB J April 28:LB399.

About LifeVantage Corporation

LifeVantage Corporation (LFVN), a leader in Nrf2 science and the maker of Protandim((R), the Nrf2 Synergizer(R) patented dietary supplement, TrueScienceTM Anti-Aging Skin Care Regimen with enhanced Nrf2 technologies, and LifeVantage(R) Canine Health, is a science based network marketing company. LifeVantage is dedicated to visionary science that looks to transform wellness and anti-aging internally and externally with products that dramatically reduce oxidative stress at the cellular level. LifeVantage was founded in 2003 and is headquartered in Salt Lake City, Utah.

Forward Looking Statements

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